Aggressive Early-Stage Lung Adenocarcinoma Is Characterized by Epithelial Cell Plasticity with Acquirement of Stem-Like Traits and Immune Evasion Phenotype

Researchers found that loss of lung cell lineage and gain of stem cell-like characteristics, along with mutator and immune evasion phenotypes, explained the aggressive behavior of a specific subset of lung adenocarcinoma (LUAD) that was called C1-LUAD, including early-stage disease.