Amplification of Transglutaminase 2 Enhances Tumor-Promoting Inflammation in Gastric Cancers

Scientists investigated a novel role for transglutaminase 2 (TGM2) in the development of tumor-promoting inflammation and recruitment of tumor-associated macrophages to gastric cancer (GC) tissues. When estimated by array comparative genomic hybridization and droplet digital PCR, the copy numbers of the TGM2 gene were amplified in 13.6% of GC patients and positively associated with TGM2 expression.