Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
[Critical Care]
6445212 5RTRJKZ4 items 1 apa 0 default asc 1 150917 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-0179ab67d5e38b741e276057a5b3d63d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%225RTRJKZ4%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pons%20et%20al.%22%2C%22parsedDate%22%3A%222020-06-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%202em%3B%20text-indent%3A-2em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPons%2C%20S.%2C%20Fodil%2C%20S.%2C%20Azoulay%2C%20E.%2C%20%26amp%3B%20Zafrani%2C%20L.%20%282020%29.%20The%20vascular%20endothelium%3A%20the%20cornerstone%20of%20organ%20dysfunction%20in%20severe%20SARS-CoV-2%20infection.%20%3Ci%3ECritical%20Care%3C%5C%2Fi%3E%2C%20%3Ci%3E24%3C%5C%2Fi%3E%281%29%2C%20353.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13054-020-03062-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13054-020-03062-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D5RTRJKZ4%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20vascular%20endothelium%3A%20the%20cornerstone%20of%20organ%20dysfunction%20in%20severe%20SARS-CoV-2%20infection%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Pons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofiane%22%2C%22lastName%22%3A%22Fodil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elie%22%2C%22lastName%22%3A%22Azoulay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lara%22%2C%22lastName%22%3A%22Zafrani%22%7D%5D%2C%22abstractNote%22%3A%22In%20severe%20SARS-CoV-2%20infections%2C%20emerging%20data%20including%20recent%20histopathological%20studies%20have%20emphasized%20the%20crucial%20role%20of%20endothelial%20cells%20%28ECs%29%20in%20vascular%20dysfunction%2C%20immunothrombosis%2C%20and%20inflammation.%22%2C%22date%22%3A%22June%2016%2C%202020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13054-020-03062-7%22%2C%22ISSN%22%3A%221364-8535%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13054-020-03062-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-06-17T18%3A09%3A15Z%22%7D%7D%5D%7DPons, S., Fodil, S., Azoulay, E., & Zafrani, L. (2020). The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection.
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https://doi.org/10.1186/s13054-020-03062-7 Cite