The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]
6445212 {6445212:EX5NFIJL} items 1 apa 0 default asc 1 150882 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-02fe8135f4b905c2ff2368a06285d324%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22EX5NFIJL%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bajetto%20et%20al.%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%202em%3B%20text-indent%3A-2em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBajetto%2C%20A.%2C%20Thellung%2C%20S.%2C%20Dellacasagrande%2C%20I.%2C%20Pagano%2C%20A.%2C%20Barbieri%2C%20F.%2C%20%26amp%3B%20Florio%2C%20T.%20%28n.d.%29.%20Cross%20talk%20between%20mesenchymal%20and%20glioblastoma%20stem%20cells%3A%20Communication%20beyond%20controversies.%20%3Ci%3ESTEM%20CELLS%20Translational%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fsctm.20-0161%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fsctm.20-0161%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DEX5NFIJL%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cross%20talk%20between%20mesenchymal%20and%20glioblastoma%20stem%20cells%3A%20Communication%20beyond%20controversies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adriana%22%2C%22lastName%22%3A%22Bajetto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Thellung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Dellacasagrande%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aldo%22%2C%22lastName%22%3A%22Pagano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Federica%22%2C%22lastName%22%3A%22Barbieri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tullio%22%2C%22lastName%22%3A%22Florio%22%7D%5D%2C%22abstractNote%22%3A%22Mesenchymal%20stem%20cells%20%28MSCs%29%20can%20be%20isolated%20from%20bone%20marrow%20or%20other%20adult%20tissues%20%28adipose%20tissue%2C%20dental%20pulp%2C%20amniotic%20fluid%2C%20and%20umbilical%20cord%29.%20In%20vitro%2C%20MSCs%20grow%20as%20adherent%20cells%2C%20display%20fibroblast-like%20morphology%2C%20and%20self-renew%2C%20undergoing%20specific%20mesodermal%20differentiation.%20High%20heterogeneity%20of%20MSCs%20from%20different%20origin%2C%20and%20differences%20in%20preparation%20techniques%2C%20make%20difficult%20to%20uniform%20their%20functional%20properties%20for%20therapeutic%20purposes.%20Immunomodulatory%2C%20migratory%2C%20and%20differentiation%20ability%2C%20fueled%20clinical%20MSC%20application%20in%20regenerative%20medicine%2C%20whereas%20beneficial%20effects%20are%20currently%20mainly%20ascribed%20to%20their%20secretome%20and%20extracellular%20vesicles.%20MSC%20translational%20potential%20in%20cancer%20therapy%20exploits%20putative%20anti-tumor%20activity%20and%20inherent%20tropism%20toward%20tumor%20sites%20to%20deliver%20cytotoxic%20drugs.%20However%2C%20controversial%20results%20emerged%20evaluating%20either%20the%20therapeutic%20potential%20or%20homing%20efficiency%20of%20MSCs%2C%20as%20both%20antitumor%20and%20protumor%20effects%20were%20reported.%20Glioblastoma%20%28GBM%29%20is%20the%20most%20malignant%20brain%20tumor%20and%20its%20development%20and%20aggressive%20nature%20is%20sustained%20by%20cancer%20stem%20cells%20%28CSCs%29%20and%20the%20identification%20of%20effective%20therapeutic%20is%20required.%20MSC%20dualistic%20action%2C%20tumor-promoting%20or%20tumor-targeting%2C%20is%20dependent%20on%20secreted%20factors%20and%20extracellular%20vesicles%20driving%20a%20complex%20cross%20talk%20between%20MSCs%20and%20GBM%20CSCs.%20Tumor-tropic%20ability%20of%20MSCs%2C%20besides%20providing%20an%20alternative%20therapeutic%20approach%2C%20could%20represent%20a%20tool%20to%20understand%20the%20biology%20of%20GBM%20CSCs%20and%20related%20paracrine%20mechanisms%2C%20underpinning%20MSC-GBM%20interactions.%20In%20this%20review%2C%20recent%20findings%20on%20the%20complex%20nature%20of%20MSCs%20will%20be%20highlighted%2C%20focusing%20on%20their%20elusive%20impact%20on%20GBM%20progression%20and%20aggressiveness%20by%20direct%20cell-cell%20interaction%20and%20via%20secretome%2C%20also%20facing%20the%20perspectives%20and%20challenges%20in%20treatment%20strategies.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fsctm.20-0161%22%2C%22ISSN%22%3A%222157-6580%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fstemcellsjournals.onlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fsctm.20-0161%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-06-18T17%3A10%3A54Z%22%7D%7D%5D%7D
Bajetto, A., Thellung, S., Dellacasagrande, I., Pagano, A., Barbieri, F., & Florio, T. (n.d.). Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0161 Cite