FGF-2–Dependent Signaling Activated in Aged Human Skeletal Muscle Promotes Intramuscular Adipogenesis

Using multiple screening assays upstream and downstream of miR-29a signaling, investigators located the secreted protein and adipogenic inhibitor SPARC to an fibroblast growth factor-2 (FGF-2) signaling pathway that was conserved between skeletal muscle cells from mice and humans and that was activated in skeletal muscle of aged mice and humans.