Mechanisms and Disease Consequences of Nonalcoholic Fatty Liver Disease

Investigators provide an in-depth discussion of the underlying pathogenetic mechanisms that lead to progressive liver injury, including the metabolic origins of Nonalcoholic fatty liver disease (NAFLD), the effect of NAFLD on hepatic glucose and lipid metabolism, bile acid toxicity, macrophage dysfunction, and hepatic stellate cell activation, and consider the role of genetic, epigenetic, and environmental factors that promote fibrosis progression and risk of hepatocellular carcinoma in nonalcoholic steatohepatitis.