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Pulmonary Cell NewsInvestigators explored the use of prime editing in human organoids. Common TP53 mutations can be correctly modeled in human adult stem cell–derived colonic organoids with efficiencies up to 25% and up to 97% in hepatocyte organoids.
[Life Science Alliance]
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Geurts, M. H., Poel, E. de, Pleguezuelos-Manzano, C., Oka, R., Carrillo, L., Andersson-Rolf, A., Boretto, M., Brunsveld, J. E., Boxtel, R. van, Beekman, J. M., & Clevers, H. (2021). Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids. Life Science Alliance, 4(10). https://doi.org/10.26508/lsa.202000940 Cite
