Patient tumor organoids (PTO) were fabricated using unsorted tumor cells with and without enrichment with patient matched immune components derived from peripheral blood leukocytes, spleen, or lymph nodes.
[Clinical Cancer Research]
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Forsythe, S. D., Erali, R. A., Sasikumar, S., Laney, P., Shelkey, E., D’Agostino, R., Miller, L. D., Shen, P., Levine, E. A., Soker, S., & Votanopoulos, K. I. (2021). Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0982 Cite