Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsTo explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
[Scientific Reports]
6445212 XH9ST9VH items 1 apa 0 default asc 1 150906 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-134af1425ec0e362a1985b54ddf01886%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22XH9ST9VH%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Uni%20et%20al.%22%2C%22parsedDate%22%3A%222020-06-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%202em%3B%20text-indent%3A-2em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EUni%2C%20R.%2C%20Inoue%2C%20T.%2C%20Nakamura%2C%20Y.%2C%20Fukaya%2C%20D.%2C%20Hasegawa%2C%20S.%2C%20Wu%2C%20C.-H.%2C%20%26%23x2026%3B%20Inagi%2C%20R.%20%282020%29.%20Vagus%20nerve%20stimulation%20even%20after%20injury%20ameliorates%20cisplatin-induced%20nephropathy%20via%20reducing%20macrophage%20infiltration.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%281%29%2C%209472.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-66295-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-66295-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DXH9ST9VH%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vagus%20nerve%20stimulation%20even%20after%20injury%20ameliorates%20cisplatin-induced%20nephropathy%20via%20reducing%20macrophage%20infiltration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rie%22%2C%22lastName%22%3A%22Uni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tsuyoshi%22%2C%22lastName%22%3A%22Inoue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuna%22%2C%22lastName%22%3A%22Nakamura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daichi%22%2C%22lastName%22%3A%22Fukaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sho%22%2C%22lastName%22%3A%22Hasegawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chia-Hsien%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rie%22%2C%22lastName%22%3A%22Fujii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bongkod%22%2C%22lastName%22%3A%22Surattichaiyakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wachirasek%22%2C%22lastName%22%3A%22Peerapanyasut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atsuko%22%2C%22lastName%22%3A%22Ozeki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nobuyoshi%22%2C%22lastName%22%3A%22Akimitsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Youichiro%22%2C%22lastName%22%3A%22Wada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masaomi%22%2C%22lastName%22%3A%22Nangaku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reiko%22%2C%22lastName%22%3A%22Inagi%22%7D%5D%2C%22abstractNote%22%3A%22The%20efficacy%20of%20prior%20activation%20of%20an%20anti-inflammatory%20pathway%20called%20the%20cholinergic%20anti-inflammatory%20pathway%20%28CAP%29%20through%20vagus%20nerve%20stimulation%20%28VNS%29%20has%20been%20reported%20in%20renal%20ischemia-reperfusion%20injury%20models.%20However%2C%20there%20have%20been%20no%20reports%20that%20have%20demonstrated%20the%20effectiveness%20of%20VNS%20after%20injury.%20We%20investigated%20the%20renoprotective%20effect%20of%20VNS%20in%20a%20cisplatin-induced%20nephropathy%20model.%20C57BL%5C%2F6%20mice%20were%20injected%20with%20cisplatin%2C%20and%20VNS%20was%20conducted%2024%5Cu2009hours%20later.%20Kidney%20function%2C%20histology%2C%20and%20a%20kidney%20injury%20marker%20%28Kim-1%29%20were%20evaluated%2072%5Cu2009hours%20after%20cisplatin%20administration.%20To%20further%20explore%20the%20role%20of%20the%20spleen%20and%20splenic%20macrophages%2C%20key%20players%20in%20the%20CAP%2C%20splenectomy%2C%20and%20adoptive%20transfer%20of%20macrophages%20treated%20with%20the%20selective%20%5Cu03b17%20nicotinic%20acetylcholine%20receptor%20agonist%20GTS-21%20were%20conducted.%20VNS%20treatment%20significantly%20suppressed%20cisplatin-induced%20kidney%20injury.%20This%20effect%20was%20abolished%20by%20splenectomy%2C%20while%20adoptive%20transfer%20of%20GTS-21-treated%20macrophages%20improved%20renal%20outcomes.%20VNS%20also%20reduced%20the%20expression%20of%20cytokines%20and%20chemokines%2C%20including%20CCL2%2C%20which%20is%20a%20potent%20chemokine%20attracting%20monocytes%5C%2Fmacrophages%2C%20accompanied%20by%20a%20decline%20in%20the%20number%20of%20infiltrating%20macrophages.%20Taken%20together%2C%20stimulation%20of%20the%20CAP%20protected%20the%20kidney%20even%20after%20injury%20in%20a%20cisplatin-induced%20nephropathy%20model.%20Considering%20the%20feasibility%20and%20anti-inflammatory%20effects%20of%20VNS%2C%20the%20findings%20suggest%20that%20VNS%20may%20be%20a%20promising%20therapeutic%20tool%20for%20acute%20kidney%20injury.%22%2C%22date%22%3A%222020-06-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-020-66295-0%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-020-66295-0%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-06-19T17%3A16%3A35Z%22%7D%7D%5D%7D
Uni, R., Inoue, T., Nakamura, Y., Fukaya, D., Hasegawa, S., Wu, C.-H., … Inagi, R. (2020). Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration. Scientific Reports, 10(1), 9472. https://doi.org/10.1038/s41598-020-66295-0 Cite
