Using mouse in utero electroporation technique and in vitro human neural stem cell (NSC) differentiation models including cerebral organoids, investigators showed that regulator of cell cycle modulated NSC self-renewal and neuronal differentiation by affecting cell cycle regulation and spindle orientation.
[EMBO Journal]
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RGCC balances self-renewal and neuronal differentiation of neural stem cells in the developing mammalian neocortex. (2021). EMBO Reports, n/a(n/a), e51781. https://doi.org/10.15252/embr.202051781 Cite