3D vascularized pancreatic adenocarcinoma tissue was microengineered in a tri-culture system composed of patient-derived pancreatic organoids, human fibroblasts, and endothelial cells on a perfusable platform, situated in a 96-well plate.
[Advanced Functional Materials]
6445212 Z89HCR5P items 1 apa 0 default asc 1 163173 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-61d823b456ac602c34b645fc49d5eb0b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22Z89HCR5P%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nakagami%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENakagami%2C%20H.%2C%20Hayashi%2C%20H.%2C%20Shimamura%2C%20M.%2C%20Rakugi%2C%20H.%2C%20%26amp%3B%20Morishita%2C%20R.%20%282021%29.%20Therapeutic%20vaccine%20for%20chronic%20diseases%20after%20the%20COVID-19%20Era.%20%3Ci%3EHypertension%20Research%3C%5C%2Fi%3E%2C%201%26%23x2013%3B7.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41440-021-00677-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41440-021-00677-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DZ89HCR5P%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Therapeutic%20vaccine%20for%20chronic%20diseases%20after%20the%20COVID-19%20Era%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hironori%22%2C%22lastName%22%3A%22Nakagami%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroki%22%2C%22lastName%22%3A%22Hayashi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Munehisa%22%2C%22lastName%22%3A%22Shimamura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiromi%22%2C%22lastName%22%3A%22Rakugi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryuichi%22%2C%22lastName%22%3A%22Morishita%22%7D%5D%2C%22abstractNote%22%3A%22There%20is%20currently%20a%20respiratory%20disease%20outbreak%20caused%20by%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-CoV-2%29.%20After%20rapid%20development%2C%20RNA%20vaccines%20and%20adenoviral%20vector%20vaccines%20were%20approved%20within%20a%20year%2C%20which%20has%20demonstrated%20the%20strong%20impact%20of%20preventing%20infectious%20diseases%20using%20gene%20therapy%20technology.%20Furthermore%2C%20intensive%20immunological%20analysis%20has%20been%20performed%20to%20evaluate%20the%20efficiency%20and%20safety%20of%20these%20vaccines%2C%20potentially%20allowing%20for%20rapid%20progress%20in%20vaccine%20technology.%20After%20the%20coronavirus%20disease%202019%20%28COVID-19%29%20era%2C%20the%20novel%20vaccine%20technology%20developed%20will%20expand%20to%20other%20vaccines.%20We%20have%20been%20developing%20vaccines%20for%20chronic%20diseases%2C%20such%20as%20hypertension%2C%20for%20%3E10%20years.%20Regarding%20the%20development%20of%20vaccines%20against%20self-antigens%20%28i.e.%2C%20angiotensin%20II%29%2C%20the%20vaccine%20should%20efficiently%20induce%20a%20blocking%20antibody%20response%20against%20the%20self-antigen%20without%20activating%20cytotoxic%20T%20cells.%20Therefore%2C%20the%20epitope%20vaccine%20approach%20has%20been%20proposed%20to%20induce%20antibody%20production%20in%20response%20to%20a%20combination%20of%20a%20B%20cell%20epitope%20and%20exogenous%20T%20cell%20epitopes%20through%20major%20histocompatibility%20complex%20molecules.%20When%20these%20vaccines%20are%20established%20as%20therapeutic%20options%20for%20hypertension%2C%20their%20administration%20regimen%2C%20which%20might%20be%20a%20few%20times%20per%20year%2C%20will%20replace%20daily%20medication%20use.%20Thus%2C%20therapeutic%20vaccines%20for%20hypertension%20may%20be%20a%20novel%20option%20to%20control%20the%20progression%20of%20cerebrovascular%20diseases.%20Hopefully%2C%20the%20accumulation%20of%20immunological%20findings%20and%20vaccine%20technology%20advances%20due%20to%20COVID-19%20will%20provide%20a%20novel%20concept%20for%20vaccines%20for%20chronic%20diseases.%22%2C%22date%22%3A%222021-06-08%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41440-021-00677-3%22%2C%22ISSN%22%3A%221348-4214%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41440-021-00677-3%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-08T16%3A20%3A41Z%22%7D%7D%5D%7D
Nakagami, H., Hayashi, H., Shimamura, M., Rakugi, H., & Morishita, R. (2021). Therapeutic vaccine for chronic diseases after the COVID-19 Era. Hypertension Research, 1–7. https://doi.org/10.1038/s41440-021-00677-3 Cite