Tag results:
B cells
Human Immunology News
Importance of Lymphocyte–Stromal Cell Interactions in Autoimmune and Inflammatory Rheumatic Diseases
[Nature Reviews Rheumatology] The authors describe the importance of lymphocyte-stromal cell interactions in chronic inflammation, with a focus on human disease, using three selected autoimmune and inflammatory diseases.
Immunology of Infectious Disease News
SARS-CoV-2 Specific T Cell Responses Are Lower in Children and Increase with Age and Time after Infection
[Nature Communications] Scientists reported SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8+ T cell responses increase with time post-infection.
Mammary Cell News
A Novel Chemical Inhibitor Suppresses Breast Cancer Cell Growth and Metastasis through Inhibiting HPIP Oncoprotein
[Cell Death Discovery] The authors screened compounds inhibiting breast cancer cell proliferation with hematopoietic PBX-interacting protein (HPIP) fused with green fluorescent protein as a reporter. A novel agent named TXX-1-10 derived from rimonabant was discovered to reduce HPIP expression and had greater inhibitory effects on breast cancer cell growth and metastasis in vitro and in vivo than rimonabant.
Immune Regulation News
Pax5 Regulates B Cell Immunity by Promoting PI3K Signaling via PTEN Down-Regulation
[Science Immunology] Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.
Dermal Cell News
Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases
[Journal of Investigative Dermatology] Increased autoantigen presentation by HLA molecules, cross-activation of pathogen-induced T cells against autologous structures, altered metabolism of self-proteins, and excessive production of proinflammatory signals may all contribute to the breakdown of immune tolerance and the development of autoimmune skin diseases.
Cell Therapy News
Lymphoid and Myeloid Immune Cell Reconstitution after Nicotinamide-Expanded Cord Blood Transplantation
[Bone Marrow Transplantation] Investigators evaluated the immune reconstitution of patients receiving omidubicel grafts during the first six months post-transplant, as IR is critical for favorable outcomes of the procedure.