EMT

[Carcinogenesis] Researchers investigated the role of CDKN2B-AS1 and the underlying mechanism in human colorectal cancer. Gain- and loss-of-function assays were performed to explore the role of CDKN2B-AS1 in the malignant behavior of HCT116 and SW480 CRC cells in vitro and in vivo.

[Oncogene] Through functional, transcriptomic, epigenomic, and proteomic analyses, researchers showed that prolyl hydroxylation of YAP1 played a critical role in the suppression of cell migration, invasion, and metastasis in prostate cancer.

[Acta Pharmacologica Sinica] By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.

[Scientific Reports] Scientists analyzed plasma proteome of colorectal cancer (CRC) patients according to disease progression, HCT116 cancer secretome upon matrix metalloproteinase-2 (MMP-2) knockdown, and publicly available CRC tissue proteome data.

[Proceedings of the National Academy of Sciences of the United States of America] Employing the mouse mammary tumor virus]–PyMT mouse model of metastatic breast cancer, scientists compared the complete elimination of β-catenin with the specific ablation of its signaling outputs in mammary tumor cells.

[Cell Death & Disease] Scientists investigated the role of circular RNA (circRNAs) which shared the same pre-mRNA with Sp1 transcription factor (SP1) in colorectal cancer (CRC) cells and identified that hsa_circ_0026628, a circRNA that originated from SP1 pre-mRNA, was upregulated in CRC cells.