GWAS

[Ebiomedicine] Florescence-activated flow cytometry analysis, immunofluorescence and organoid culture system were performed to identify the β-catenin/Wnt-activated cells in Fam13a+/+ or Fam13a−/− mice exposed to CS.

[Nature Communications] The authors studied endocrine immune related adverse events from seven clinical trials across six cancers where atezolizumab was combined with chemotherapies and compared to standard of care.

[NPJ Genomic Medicine] Scientists identified a genetic association between decreased expression of GDF5 and anthracycline-induced cardiotoxicity, and found that cell viability of GDF5-silenced human cardiac myocytes was significantly decreased in response to anthracycline treatment.

[The American Journal of Human Genetics] Researchers mapped caQTLs in human liver tissue in 20 liver samples and identified 3,123 caQTLs.

[American Journal of Human Genetics] Researchers discovered 14 single variant-red blood cell trait associations at 12 genomic loci, which have not been reported previously.

[Molecular Psychiatry] Investigators utilized an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta peptides in hiPSC-derived neural cultures.