Lgr5

[Cancer Gene Therapy] Investigators proposed that geminin overexpression in normal mammary epithelial cells promoted the generation of TNBC metastatic precursors that home specifically to lungs by upregulating LGR5 expression and promoting stemness, intravasation, and extravasation in these precursors.

[Molecular Carcinogenesis] Scientists showed that Twist1 had a direct role in maintaining the balance between proliferation and differentiation of keratinocytes and keratinocyte stem/progenitor populations.

[Nature] To determine the physiological role of MAP3K2-regulated intestinal stromal cells (MRISCs), scientists co-cultured MRISCs with colonic organoids and found that organoid growth was greater than when co-cultured with MRISC-depleted stromal cells

[Hepatology] The authors summarize currently available adult cell‐derived hepatobiliary organoid models and their applications.

[Oncogene] The authors found that IL-17RB expression was significantly upregulated in spheroid cells and Lgr5-positive cells from the same tumor tissues of patients with gastric cancer, which was closely correlated with the degree of cancer cell differentiation.

[Cell Reports] Using a Lgr5-2A-DTR model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 expression, researchers showed that persistent depletion of Lgr5+ intestinal stem cells in fact compromised small intestinal epithelial integrity and reduced epithelial turnover in vivo.