MAPK

[Scientific Reports] Investigators used peripheral blood and bone marrow samples from patients with acute myeloid leukemia (AML) to analyze the impact of CD157-directed antibodies in AML survival and in response to cytarabine ex vivo.

[Cell Death & Disease] Scientists evaluated the specific regulatory mechanisms of exosomal miR-338-3p/CHL1/MAPK signaling pathway axis in NSCLC. In vitro MTS and apoptotic assays were used to investigate the functions of CHL1 and exosomal miR-338-3p in NSCLC progression.

[Cancer Research] Researchers showed that testosterone promotes melanoma proliferation by activating ZIP9 (SLC39A9), a zinc transporter that is widely expressed in human melanoma but not intentionally targeted by available therapeutics.

[Matrix Biology] Investigators indicated that elevated TGFβ signaling led to an attenuated response to growth factors, which contributed to impaired dermal wound healing in recessive dystrophic epidermolysis bullosa.

[Cell Death & Disease] Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. The authors showed that Ephexin1 was highly expressed in colorectal cancer and lung cancer patient tissues.

[Cell Death Discovery] Researchers determined the clinical value, biological functions, and potential mechanisms of RNA-binding motif protein 15 (RBM15) in hepatocellular carcinoma.