PBMCs

[Cancer Immunology Research] Researchers used multicolor flow cytometry and immunohistochemistry to elucidate abundance and spatial distribution of these antigen-presenting B cells in blood and tumor samples of 238 cancer patients.

[Bioheng Biotech Co., Ltd.] Nanjing Bioheng Biotech Co., Ltd. announced UCAR T cell therapy product targeting CD7, received Orphan Drug Designation from the US FDA for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).

[Cancer Immunology Immunotherapy] Scientists reported results from a phase I/II clinical trial in which six metastatic HLA-A2 melanoma patients received autologous antigen-specific T-cells produced from peripheral blood mononuclear cells, after peptide stimulation in vitro, followed by sorting with HLA-peptide multimers and amplification.

[Tissue Engineering and Regenerative Medicine] IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.

[Scientific Reports] The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.

[Journal of Experimental Medicine] The authors discovered two novel V-domain Ig suppressor of T cell activation (VISTA) antibodies and characterized their effects on human peripheral blood mononuclear cells by scRNA/CITE-seq.