Scientists reported results from a phase I/II clinical trial in which six metastatic HLA-A2 melanoma patients received autologous antigen-specific T-cells produced from peripheral blood mononuclear cells, after peptide stimulation in vitro, followed by sorting with HLA-peptide multimers and amplification.
[Cancer Immunology Immunotherapy]
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Dréno, B., Khammari, A., Fortun, A., Vignard, V., Saiagh, S., Beauvais, T., Jouand, N., Bercegay, S., Simon, S., Lang, F., & Labarrière, N. (2021). Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-02961-0 Cite