Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors discovered two novel V-domain Ig suppressor of T cell activation (VISTA) antibodies and characterized their effects on human peripheral blood mononuclear cells by scRNA/CITE-seq.
[Journal of Experimental Medicine]
6445218 {6445218:KH2MEZ4L} apa 50 1 163309 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ba747f35366145c15e468c9f4578b71d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KH2MEZ4L%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rogers%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERogers%2C%20B.%20M.%2C%20Smith%2C%20L.%2C%20Dezso%2C%20Z.%2C%20Shi%2C%20X.%2C%20DiGiammarino%2C%20E.%2C%20Nguyen%2C%20D.%2C%20Sethuraman%2C%20S.%2C%20Zheng%2C%20P.%2C%20Choi%2C%20D.%2C%20Zhang%2C%20D.%2C%20Nguyen%2C%20A.%2C%20McGuire%2C%20K.%2C%20Liu%2C%20W.%2C%20Chung%2C%20N.%2C%20Chao%2C%20D.%20T.%2C%20Ye%2C%20S.%2C%20%26amp%3B%20Starbeck-Miller%2C%20G.%20R.%20%282021%29.%20VISTA%20is%20an%20activating%20receptor%20in%20human%20monocytes.%20%3Ci%3EJournal%20of%20Experimental%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E218%3C%5C%2Fi%3E%288%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1084%5C%2Fjem.20201601%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1084%5C%2Fjem.20201601%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DKH2MEZ4L%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22VISTA%20is%20an%20activating%20receptor%20in%20human%20monocytes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bryan%20M.%22%2C%22lastName%22%3A%22Rogers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zoltan%22%2C%22lastName%22%3A%22Dezso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xu%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22DiGiammarino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denny%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sunantha%22%2C%22lastName%22%3A%22Sethuraman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pingping%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donghee%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dong%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathleen%22%2C%22lastName%22%3A%22McGuire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Namjin%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debra%20T.%22%2C%22lastName%22%3A%22Chao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shiming%22%2C%22lastName%22%3A%22Ye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%20R.%22%2C%22lastName%22%3A%22Starbeck-Miller%22%7D%5D%2C%22abstractNote%22%3A%22As%20indicated%20by%20its%20name%2C%20V-domain%20Ig%20suppressor%20of%20T%20cell%20activation%20%28VISTA%29%20is%20thought%20to%20serve%20primarily%20as%20an%20inhibitory%20protein%20that%20limits%20immune%20responses.%20VISTA%20antibodies%20can%20dampen%20the%20effects%20of%20several%20concomitantly%20elicited%20activation%20signals%2C%20including%20TCR%20and%20TLR%20activation%2C%20but%20it%20is%20currently%20unclear%20if%20VISTA%20agonism%20could%20singly%20affect%20immune%20cell%20biology.%20In%20this%20study%2C%20we%20discovered%20two%20novel%20VISTA%20antibodies%20and%20characterized%20their%20effects%20on%20human%20peripheral%20blood%20mononuclear%20cells%20by%20scRNA%5C%2FCITE-seq.%20Both%20antibodies%20appeared%20to%20agonize%20VISTA%20in%20an%20Fc-functional%20manner%20to%20elicit%20transcriptional%20and%20functional%20changes%20in%20monocytes%20consistent%20with%20activation.%20We%20also%20used%20pentameric%20VISTA%20to%20identify%20Syndecan-2%20and%20several%20heparan%20sulfate%20proteoglycan%20synthesis%20genes%20as%20novel%20regulators%20of%20VISTA%20interactions%20with%20monocytic%20cells%2C%20adding%20further%20evidence%20of%20bidirectional%20signaling.%20Together%2C%20our%20study%20highlights%20several%20novel%20aspects%20of%20VISTA%20biology%20that%20have%20yet%20to%20be%20uncovered%20in%20myeloid%20cells%20and%20serves%20as%20a%20foundation%20for%20future%20research.%22%2C%22date%22%3A%22June%209%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1084%5C%2Fjem.20201601%22%2C%22ISSN%22%3A%220022-1007%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1084%5C%2Fjem.20201601%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-10T19%3A22%3A14Z%22%7D%7D%5D%7D
Rogers, B. M., Smith, L., Dezso, Z., Shi, X., DiGiammarino, E., Nguyen, D., Sethuraman, S., Zheng, P., Choi, D., Zhang, D., Nguyen, A., McGuire, K., Liu, W., Chung, N., Chao, D. T., Ye, S., & Starbeck-Miller, G. R. (2021). VISTA is an activating receptor in human monocytes. Journal of Experimental Medicine, 218(8). https://doi.org/10.1084/jem.20201601 Cite
