PBMCs

[Journal of Clinical Investigation] SIRT6-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease.

[American Journal of Hematology] The authors developed a murine model to investigate the in vivo properties of human iPSC-red blood cells (RBCs). iPSC lines were produced from human peripheral blood mononuclear cells by transient expression of plasmids containing OCT4, SOX2, MYC, KLF4 and BCL-XL genes.

[Frontiers in Cell and Developmental Biology] The authors used a tripartite model of human hepatocellular carcinoma cell line and mesenchymal stromal cells co-cultured with peripheral blood mononuclear cells to investigate the impact of tumor and stromal cell interactions to the development of immunosuppressive tumor microenvironment.

[Science Advances] The authors reported the impact of the interaction between serotonin [5-hydroxytryptamine;(5-HT)] and autophagy in colitis in mouse and human studies.

[PLoS One] Researchers studied the effect of dietary salt loading on inflammatory process and related extracellular matrix remodeling in the skin. The effect of high salt concentration on dermal fibroblasts and peripheral blood mononuclear cells was investigated in vitro.

[Science Advances] Factors that lead to the development of impaired autophagy during intestinal inflammation remain largely unexplored. Researchers reported the impact of the interaction between serotonin and autophagy in colitis in mouse and human studies.