SIRT6 Protects Vascular Smooth Muscle Cell from Osteogenic Transdifferentiation via Runx2 in Chronic Kidney Disease

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SIRT6-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease.
[Journal of Clinical Investigation]
AbstractGraphical Abstract