Tag results:
RAS
Intestinal Cell News
RAS Specific Protease Induces Irreversible Growth Arrest via p27 in Several KRAS Mutant Colorectal Cancer Cell Lines
[Scientific Reports] Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.
Cancer Stem Cell News
Sulfarotene, a Synthetic Retinoid, Overcomes Stemness and Sorafenib Resistance of Hepatocellular Carcinoma via Suppressing SOS2-RAS Pathway
[Journal of Experimental & Clinical Cancer Research] Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
Cancer Stem Cell News
Colon Adenocarcinoma-Derived Cells Possessing Stem Cell Function Can Be Modulated Using Renin-Angiotensin System Inhibitors
[PLoS One] Primary cell lines derived from four high-grade colon adenocarcinoma tissues were treated with renin-angiotensin system inhibitors to investigate their effect on cellular metabolism, tumorsphere formation and transcription of pluripotency genes.
Pulmonary Cell News
The Chemokine CCL1 Triggers an AMFR-SPRY1 Pathway That Promotes Differentiation of Lung Fibroblasts into Myofibroblasts and Drives Pulmonary Fibrosis
[Immunity] Scientists examined the role of CCL1 in pulmonary fibrosis (PF). Bronchoalveolar lavage fluid from PF mouse models contained high amounts of CCL1, as did lung biopsies from PF patients.
Human Immunology News
Context-Dependent Immunomodulatory Effects of MEK Inhibition are Enhanced with T-Cell Agonist Therapy
[Cancer Immunology Research] Scientists modeled tumor-specific MEK inhibition (MEKi) through CRISPR/Cas-mediated genome editing of tumor cells and pharmacologic MEKi with cobimetinib in a RAS-driven model of colorectal cancer.
Pulmonary Cell News
Vitamin D Suppresses Bleomycin-Induced Pulmonary Fibrosis by Targeting the Local Renin–Angiotensin System in the Lung
[Scientific Reports] The authors demonstrated that in lung fibroblast cultures, TGF-β and angiotensin II synergistically induced TGF-β, AT1R, α-SMA, collagen type I and fibronectin, whereas 1,25-dihydroxyvitamin D markedly suppressed the induction of these fibrotic markers.