STAT3

[Cell Death & Disease] The PERK pathway inhibits global protein synthesis while allowing translation of specific mRNAs, such as the ATF4 transcription factor.

[Purple Biotech Ltd. (GlobeNewswire, Inc.)] Purple Biotech Ltd. announced the expansion of an existing research agreement, led by Dr. Menashe Bar-Eli at The University of Texas MD Anderson Cancer Center, and will evaluate the potential efficacy of the combination of NT219, a dual inhibitor, novel small molecule that simultaneously targets IRS1/2 and STAT3, and immuno-oncology drugs, such as anti-CTLA4 or anti-PD1/PDL1 antibodies.

[Cell Chemical Biology] Researchers used a chemical proteomics strategy that had identified STAT3, a transcription factor considered to be undruggable, as a direct functional protein target of rapamycin. They showed that rapamycin treatment in cell culture significantly inhibited c-Myc-regulated gene expression.

[Nature Communications] Investigators showed that optineurin was upregulated in human and mouse dendritic cell (DC) maturation, and that deletion of Optn in mice via CD11c-Cre attenuated DC maturation and impaired the priming of CD4+ T cells, thus ameliorating autoimmune symptoms such as experimental autoimmune encephalomyelitis.

[Molecular Oncology] As toll-like receptor 4 (TLR4) agonists are known to regress solid tumors, scientists observed that lipopolysaccharide induced TOPORS via a TLR4–TRIF-dependent pathway, which in turn modulated the transcription of tumor suppressor scaffold/matrix attachment region-binding protein 1.

[Cell Death & Disease] Researchers confirmed the downregulation of miR-193b-3p in psoriasis patients, psoriasis-like inflammatory cellular models, and an imiquimod-induced mouse model.