T cells

[Proceedings of the National Academy of Sciences of the United States of America] In vitro studies demonstrated that IFP35 and NMI were released by multiple cells. IFP35 and NMI subsequently triggered nuclear factor kappa B–dependent activation of microglia via the TLR4 pathway.

[Nature Communications] Scientists showed that the deubiquitinase USP12 was commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.

[Cell Metabolism] Investigators compared glucose metabolism in hematopoiesis and leukemia. Thymus T cell progenitors were glucose avid and oxidized more glucose in the tricarboxylic acid cycle through pyruvate dehydrogenase as compared with other hematopoietic cells.

[Blood Advances] Researchers reported two cases of the serial use of anti-B-cell maturation antigen (BCMA) therapies with parallel monitoring of BCMA expression and anti-CAR antibodies and discussed recent data from clinical studies about the different mechanisms of resistance to anti-BCMA therapies.

[Nature Communications] Researchers showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activate T cells to levels observed with classical DCs.

[Blood] To target CD70 on acute myeloid leukemia cells, researchers generated a panel of CD70-CAR T cells that contained a common single-chain variable fragment for antigen detection, but differed in size and flexibility of the extracellular spacer and in the transmembrane and the costimulatory domains.