USP12 Downregulation Orchestrates a Protumourigenic Microenvironment and Enhances Lung Tumor Resistance to PD-1 Blockade

Scientists showed that the deubiquitinase USP12 was commonly downregulated in the Kras^G12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.