YAP

[EMBO Journal] Researchers demonstrated that YAP/TAZ activation reprogrammed airway secretory cells, which subsequently lost their cellular identity and acquired squamous alveolar type 1 fate in the lung.

[Molecular and Cellular Endocrinology] Researchers showed that glucocorticoids suppressed cardiomyocyte (CM) proliferation in vitro and in vivo, decreased the total number of CMs, and increased the cross-sectional area of CMs.

[Stem Cells] Scientists provide knowledge of the regulatory mechanisms that control substrate partitioning to coordinate biosynthesis with energy provision could be leveraged to prompt or augment cardiomyocyte division and to promote cardiac repair.

[Nature Communications] Researchers uncovered that Fusobacterium nucleatum induced a dramatic decline of m6A modifications in CRC cells and patient-derived xenograft tissues by downregulation of an m6A methyltransferase METTL3, contributing to inducation of CRC aggressiveness.

[Frontiers in Cell and Developmental Biology] Using biomimetic ECM hydrogels with tunable stiffness, investigators showed that increased ECM stiffness elevated Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) nuclear localization potentially through modulating focal adhesions and cytoskeletal rearrangement.

[Advanced Science] The authors reported a robust method to convert fibroblasts to neurons through targeting the cytoskeleton followed by exposure to lineage-specification surroundings.