Zika

[npj Vaccines] Researchers showed that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies.

[Cell Stem Cell] Scientists used human brain organoids to study the mechanisms underlying microcephaly caused by Zika virus and herpes simplex virus.

[Nature Biotechnology] Scientists report a biological activity-based modeling approach, in which compound activity profiles established across multiple assays were used as signatures to predict compound activity in other assays or against a new target.

[npj Vaccines] The authors generated a Zika virus mutant, ZE4B-36, which combined mutations in both E glycosylation and NS4B P36.

[Science] Scientists present three crystal structures of full-length dengue virus NS1 complexed with a flavivirus–cross-reactive, NS1-specific monoclonal antibody, 2B7, at resolutions between 2.89 and 3.96 angstroms. These structures reveal a protective mechanism by which two domains of NS1 are antagonized simultaneously.

[Scientific Reports] Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. Investigators present the SCOUT pipeline for automated multiscale comparative analysis of intact cerebral organoids.