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Pulmonary Cell NewsResearchers showed that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies.
[npj Vaccines]
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Saunders, K. O., Pardi, N., Parks, R., Santra, S., Mu, Z., Sutherland, L., Scearce, R., Barr, M., Eaton, A., Hernandez, G., Goodman, D., Hogan, M. J., Tombacz, I., Gordon, D. N., Rountree, R. W., Wang, Y., Lewis, M. G., Pierson, T. C., Barbosa, C., … Haynes, B. F. (2021). Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates. Npj Vaccines, 6(1), 1–14. https://doi.org/10.1038/s41541-021-00307-6 Cite
