Biological Activity-Based Modeling Identifies Antiviral Leads against SARS-CoV-2

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Justin.choi
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Scientists report a biological activity-based modeling approach, in which compound activity profiles established across multiple assays were used as signatures to predict compound activity in other assays or against a new target.
[Nature Biotechnology]
Huang, R., Xu, M., Zhu, H., Chen, C. Z., Zhu, W., Lee, E. M., He, S., Zhang, L., Zhao, J., Shamim, K., Bougie, D., Huang, W., Xia, M., Hall, M. D., Lo, D., Simeonov, A., Austin, C. P., Qiu, X., Tang, H., & Zheng, W. (2021). Biological activity-based modeling identifies antiviral leads against SARS-CoV-2. Nature Biotechnology, 1–7. https://doi.org/10.1038/s41587-021-00839-1 Cite
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