alveolar epithelial cells

[iScience] Postnatal YAP activation increased epithelial cell proliferation, increased alveolar type-1 cell numbers, and caused indeterminate differentiation of subsets of alveolar cells expressing atypical genes normally restricted to airway epithelial cells.

[Biomaterials] The authors established an expansion system of hPSC-derived lung progenitors based on their 3D culture in core-shell hydrogel microfibers, that ensures the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II cells.

[Laboratory Investigation] In vitro, epithelial-mesenchymal transition (EMT) was induced by the administration of transforming growth factor-β1 in a human alveolar epithelial cell line.

[Ebiomedicine] Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.

[Science Advances] The authors identified growth hormone receptor is mainly expressed in mesenchymal cells, and its expression is substantially decreased in idiopathic pulmonary fibrosis lungs.

[Cell Discovery] Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages.