cell proliferation

[Bioengineered] Investigators showed that hsa_circ_0030586 was significantly upregulated in prostate cancer (PCa) cells. Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion.

[Molecular Oncology] Scientists found that both Sirtuin 1 (SIRT1) and SIRT1 phosphorylated on serine 27 were coordinately upregulated in colon cancer patients’ tissues and human colon cancer cell lines.

[Nature Communications] SHP2 inefficiency impaired endothelial cell proliferation, migration, and tubulogenesis through downregulating the expression of proangiogenic SRY-Box transcription factor 7 (SOX7), whose re-expression restored endothelial function in SHP2-knockdown cells and tumor growth, angiogenesis, and vascular abnormalization in Shp2-deleted mice.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] To address limitations in cell culture and in vivo mechanotransductive models, scientists developed two mouse lung organoid mechanotransductive models using postnatal day five mouse lung CD326-positive cells and fibroblasts subjected to increased, decreased, and cyclic strain.

[Cell Death & Disease] Researchers probed the function and potential mechanism of KCNK15-AS1 in pancreatic cancer (PC) cell growth. RT-qPCR and western blot were employed to measure gene expression in PC cells.

[Chemico-Biological interactions] Researchers investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.