coronary artery disease

[American Journal of Clinical Dermatology] Scientists evaluate the efficacy and safety of IL-23 inhibitors in the treatment of plaque psoriasis and psoriatic arthritis.

[Antioxidants] To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), scientists analyzed the in vitro effect of oxLDL on intracellular Ca2+ handling in adult rat ventricular cardiomyocytes using confocal microscopy.

[Antioxidants] To determine the intracellular mechanisms involved in the cardiac effects of oxidized low-density lipoprotein (oxLDL), the authors analyzed the in vitro effect of oxLDL on intracellular Ca2+ handling in adult rat ventricular cardiomyocytes using confocal microscopy.

[Circulation] Researchers examined expression of RIPK1 protein and mRNA in both human and mouse atherosclerotic lesions, and using loss-of-function approaches in vitro in macrophages and endothelial cells to measure inflammatory responses. They administered weekly injections of RIPK1 anti-sense oligonucleotides to Apoe-/- mice fed a cholesterol-rich diet for eight weeks.

[Circulation] To reveal the trajectories of smooth muscle cell (SMC) transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, researchers combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques.

[Cell Death & Disease] The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.