RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice

By
Justin.choi
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Researchers examined expression of RIPK1 protein and mRNA in both human and mouse atherosclerotic lesions, and using loss-of-function approaches in vitro in macrophages and endothelial cells to measure inflammatory responses. They administered weekly injections of RIPK1 anti-sense oligonucleotides to Apoe-/- mice fed a cholesterol-rich diet for eight weeks.
[Circulation]
Karunakaran Denuja, Nguyen My-Anh, Geoffrion Michele, Vreeken Dianne, Lister Zachary, Cheng Henry S., Otte Nicola, Essebier Patricia, Wyatt Hailey, Kandiah Joshua W., Jung Richard, Alenghat Francis J., Mompeon Ana, Lee Richard, Pan Calvin, Gordon Emma, Rasheed Adil, Lusis Aldons J., Liu Peter, … Rayner Katey J. (n.d.). RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.118.038379 Cite
Abstract