The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease]
6445212 {6445212:3QPVYHNP} apa 50 1 154338 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-25f8eccefcee4597905e1538f479fbc2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%223QPVYHNP%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bai%20et%20al.%22%2C%22parsedDate%22%3A%222020-09-18%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBai%2C%20B.%2C%20Yang%2C%20Y.%2C%20Wang%2C%20Q.%2C%20Li%2C%20M.%2C%20Tian%2C%20C.%2C%20Liu%2C%20Y.%2C%20Aung%2C%20L.%20H.%20H.%2C%20Li%2C%20P.%2C%20Yu%2C%20T.%2C%20%26amp%3B%20Chu%2C%20X.%20%282020%29.%20NLRP3%20inflammasome%20in%20endothelial%20dysfunction.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%289%29%2C%201%26%23x2013%3B18.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-020-02985-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-020-02985-x%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D3QPVYHNP%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22NLRP3%20inflammasome%20in%20endothelial%20dysfunction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baochen%22%2C%22lastName%22%3A%22Bai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanyan%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chao%22%2C%22lastName%22%3A%22Tian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lynn%20Htet%20Htet%22%2C%22lastName%22%3A%22Aung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pei-feng%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tao%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xian-ming%22%2C%22lastName%22%3A%22Chu%22%7D%5D%2C%22abstractNote%22%3A%22Inflammasomes%20are%20a%20class%20of%20cytosolic%20protein%20complexes.%20They%20act%20as%20cytosolic%20innate%20immune%20signal%20receptors%20to%20sense%20pathogens%20and%20initiate%20inflammatory%20responses%20under%20physiological%20and%20pathological%20conditions.%20The%20NLR-family%20pyrin%20domain-containing%20protein%203%20%28NLRP3%29%20inflammasome%20is%20the%20most%20characteristic%20multimeric%20protein%20complex.%20Its%20activation%20triggers%20the%20cleavage%20of%20pro-interleukin%20%28IL%29-1%5Cu03b2%20and%20pro-IL-18%2C%20which%20are%20mediated%20by%20caspase-1%2C%20and%20secretes%20mature%20forms%20of%20these%20mediators%20from%20cells%20to%20promote%20the%20further%20inflammatory%20process%20and%20oxidative%20stress.%20Simultaneously%2C%20cells%20undergo%20pro-inflammatory%20programmed%20cell%20death%2C%20termed%20pyroptosis.%20The%20danger%20signals%20for%20activating%20NLRP3%20inflammasome%20are%20very%20extensive%2C%20especially%20reactive%20oxygen%20species%20%28ROS%29%2C%20which%20act%20as%20an%20intermediate%20trigger%20to%20activate%20NLRP3%20inflammasome%2C%20exacerbating%20subsequent%20inflammatory%20cascades%20and%20cell%20damage.%20Vascular%20endothelium%20at%20the%20site%20of%20inflammation%20is%20actively%20involved%20in%20the%20regulation%20of%20inflammation%20progression%20with%20important%20implications%20for%20cardiovascular%20homeostasis%20as%20a%20dynamically%20adaptable%20interface.%20Endothelial%20dysfunction%20is%20a%20hallmark%20and%20predictor%20for%20cardiovascular%20ailments%20or%20adverse%20cardiovascular%20events%2C%20such%20as%20coronary%20artery%20disease%2C%20diabetes%20mellitus%2C%20hypertension%2C%20and%20hypercholesterolemia.%20The%20loss%20of%20proper%20endothelial%20function%20may%20lead%20to%20tissue%20swelling%2C%20chronic%20inflammation%2C%20and%20the%20formation%20of%20thrombi.%20As%20such%2C%20elimination%20of%20endothelial%20cell%20inflammation%20or%20activation%20is%20of%20clinical%20relevance.%20In%20this%20review%2C%20we%20provided%20a%20comprehensive%20perspective%20on%20the%20pivotal%20role%20of%20NLRP3%20inflammasome%20activation%20in%20aggravating%20oxidative%20stress%20and%20endothelial%20dysfunction%20and%20the%20possible%20underlying%20mechanisms.%20Furthermore%2C%20we%20highlighted%20the%20contribution%20of%20noncoding%20RNAs%20to%20NLRP3%20inflammasome%20activation-associated%20endothelial%20dysfunction%2C%20and%20outlined%20potential%20clinical%20drugs%20targeting%20NLRP3%20inflammasome%20involved%20in%20endothelial%20dysfunction.%20Collectively%2C%20this%20summary%20provides%20recent%20developments%20and%20perspectives%20on%20how%20NLRP3%20inflammasome%20interferes%20with%20endothelial%20dysfunction%20and%20the%20potential%20research%20value%20of%20NLRP3%20inflammasome%20as%20a%20potential%20mediator%20of%20endothelial%20dysfunction.%22%2C%22date%22%3A%222020-09-18%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-020-02985-x%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-020-02985-x%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-09-21T16%3A55%3A04Z%22%7D%7D%5D%7D
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020). NLRP3 inflammasome in endothelial dysfunction. Cell Death & Disease, 11(9), 1–18. https://doi.org/10.1038/s41419-020-02985-x Cite