fibroblasts

[Cell Death & Differentiation] The authors found that deficiency of Huwe1 in mice hepatocytes exacerbated ischemia-reperfusion injury and CCl4-induced liver injury with more ferroptosis occurrence, and that suppression of Huwe1 enhanced cellular sensitivity to ferroptosis in primary hepatocytes and mouse embryonic fibroblasts.

[Stem Cell Reviews and Reports] Researchers reported human urine cells could be converted into CM-like cells from different donors and the related chromatin accessibility dynamics by assay for transposase accessible chromatin-seq.

[Advanced Science] The authors reported a robust method to convert fibroblasts to neurons through targeting the cytoskeleton followed by exposure to lineage-specification surroundings.

[Respiratory Research] Scientists exposed mice to three weeks of continuous or intermittent cigarette smoke (CS) to identify whether different CS exposure patterns would result in differential effects on stem cells and the mechanisms underlying these potential differences.

[Science Advances] Researchers demonstrated of the use of extracellular vesicles derived from ESCs undergoing cardiac differentiation as biomimetic tools to induce cardiac reprogramming with extremely high efficiency, establishing a general, more readily accessible platform for generating a variety of specialized somatic cells through direct lineage conversion.

[Science Translational Medicine] Scientists investigated the potential role of adipogenesis by dermal fibroblasts in acne and performed single-cell RNA sequencing on human acne lesions and mouse skin challenged by Cutibacterium acnes.