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fibroblasts

Nifuroxazide Ameliorates Pulmonary Fibrosis by Blocking Myofibroblast Genesis: A Drug Repurposing Study

[Respiratory Research] In vivo, intraperitoneal injection of Nifuroxazide relieved and reversed pulmonary fibrosis caused by bleomycin bronchial instillation.

TRPC3 Shapes the ER-Mitochondria Ca2+ Transfer Characterizing Tumour-Promoting Senescence

[Nature Communications] Researchers reported the mechanism altering mitochondrial function and OXPHOS in stress-induced senescent fibroblasts.

Adaptive NK Cells Undergo a Dynamic Modulation in Response to Human Cytomegalovirus and Recruit T Cells in In Vitro Migration Assays

[Bone Marrow Transplantation] Investigators studied the relationship between human cytomegalovirus reactivation and adaptive NK cells in 70 patients monitored weekly until 100 days after hematopoietic stem cell transplantation

Modeling iPSC-Derived Human Neurofibroma-Like Tumors in Mice Uncovers the Heterogeneity of Schwann Cells within Plexiform Neurofibromas

[Cell Reports] The authors developed an iPSC-based neural crest-Schwann cell in vitro differentiation system and constructed a lineage expression roadmap for the analysis of different 2D and 3D neurofibroma models.

A Human Cell Atlas of the Pressure-Induced Hypertrophic Heart

[Nature Cardiovascular Research] Researchers presented the transcriptional response of human cardiomyocytes to pressure overload caused by aortic valve stenosis and described major alterations in cardiac cellular crosstalk.

Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer

[Cancer Research] Researchers described a mechanism by which CAF-secreted lactate was able to increase the expression of genes involved in lipid metabolism in prostate cancer cells.

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