Caspase-3/NLRP3 Signaling in the Mesenchymal Stromal Niche Regulates Myeloid-Biased Hematopoiesis

Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.
[Stem Cell Research & Therapy]
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Targeted Integration of EpCAM-Specific CAR in Human Induced Pluripotent Stem Cells and Their Differentiation into NK Cells

Scientists genetically modified human iPSCs with a zinc finger nuclease technology to introduce a cDNA encoding an anti-EpCAM chimeric antigen receptor into the adeno-associated virus integration site 1, a “safe harbour” for transgene insertion into human genome.
[Stem Cell Research & Therapy]
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Extracellular Vesicles Derived from Hypoxia-Preconditioned Olfactory Mucosa Mesenchymal Stem Cells Enhance Angiogenesis via miR-612

Investigators explored the effects of extracellular vesicles from human hypoxic olfactory mucosa MSCs on angiogenesis and its underlying mechanism.
[Journal of Nanobiotechnology]
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Vorinostat, a Histone Deacetylase Inhibitor, as a Potential Novel Treatment for Psoriasis

The authors investigated the efficacy of the histone deacetylase inhibitor, Vorinostat, in targeting hyperproliferation and impaired apoptosis in psoriatic skin.
[Experimental Dermatology]
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Ad-Apoptin Inhibits Glycolysis, Migration and Invasion in Lung Cancer Cells Targeting AMPK/mTOR Signaling Pathway

Researchers investigated the effects of Ad-apoptin on glycolysis, migration and invasion of non-small cell lung cancer.
[Experimental Cell Research]
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Empirical Identification and Validation of Tumor-Targeting T Cell Receptors from Circulation Using Autologous Pancreatic Tumor Organoids

Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.
[Journal For Immunotherapy of Cancer]
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Deep-Frying Oil Induces Cytotoxicity, Inflammation, and Apoptosis on Intestinal Epithelial Cells

Bioinformatics and cell biology were used to investigate the functions and signal pathway enrichments of differentially expressed genes.
[Journal of the Science of Food and Agriculture]
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Combination of Resveratrol and BIBR1532 Inhibits Proliferation of Colon Cancer Cells by Repressing Expression of LncRNAs

Scientists investigated the effect of resveratrol and BIBR1532, either alone or in combination, on the cell viability as well as on expression of long non-coding RNAs for HT-29 colon adenocarcinoma cells.
[Medical Oncology]
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Transcription Factor p53-Mediated Activation of miR-519d-3p and Downregulation of E2F1 Attenuates Prostate Cancer Growth and Metastasis

Investigators uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.
[Cancer Gene Therapy]
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MiR-455-5p Upregulation in Umbilical Cord Mesenchymal Stem Cells Attenuates Endometrial Injury and Promotes Repair of Damaged Endometrium via Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling

Scientists investigated the specific impacts of umbilical cord mesenchymal stem cells overexpressing miR-455-5p in intrauterine adhesions.
[Bioengineered]
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Methionine Affects the Expression of Pluripotency Genes and Protein Levels Associated with Methionine Metabolism in Adult, Fetal, and Cancer Stem Cells

Scientists revealed the differences in methionine metabolism of bone marrow (BM)-mesenchymal stem cells (MSCs), umbilical cord blood-MSCs, and cancer stem cells, which reflect different metabolic profiles and developmental stages of stem cells.
[Journal of Cellular Biochemistry]
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