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Novel Therapeutic Strategy for Melanoma Based on Albendazole and the CDK4/6 Inhibitor Palbociclib

[Scientific Reports] The authors demonstrated that albendazole, an FDA-approved broad-spectrum antiparasitic agent, significantly inhibited the proliferation of melanoma cells in vitro and in vivo.

Gastric Cancer Cell-Derived Extracellular Vesicles Elevate E2F7 Expression and Activate the MAPK/ERK Signaling to Promote Peritoneal Metastasis through the Delivery of SNHG12

[Cell Death Discovery] Scientists explored the ability of gastric cancer (GC) cell-derived extracellular vesicles (EVs)-mediated microRNA-129-5p/E2F transcription factor 7/mitogen-activated protein kinase/extracellular regulated protein kinase axis to affect the peritoneal metastasis of GC by delivering lncRNA small nucleolar RNA host gene 12.

Elevated BTG2 Improves the Radiosensitivity of Non-small Cell Lung Cancer (NSCLC) through Apoptosis

[Thoracic Cancer] Scientists identified radio-responsive genes and explored the biological function of encoded proteins in NSCLC.

Type 2 Immune Polarization Is Associated with Cardiopulmonary Disease in Preterm Infants

[Science Translational Medicine] The authors characterized blood samples collected from 51 preterm infants longitudinally at five time points, 20 healthy term infants at birth and age 3 to 16 weeks, and five healthy adults, and observed strong associations between type 2 immune polarization in circulating CD3+CD4+ T cells and cardiopulmonary illness, with odds ratios up to 24.

Transplantation of Umbilical Cord Blood-Derived Mesenchymal Stem Cells as Therapy for Adriamycin Induced-Cardiomyopathy

[Bioengineered] Scientists studied the therapeutic effects of umbilical cord blood-derived mesenchymal stem cells transplantation on adriamycin-induced cardiomyopathy.

MiR-222-3p Inhibits Formation of Medulloblastoma Stem-Like Cells by Targeting Notch2/C-myc Signaling Pathway

[Immunopharmacology and Immunotoxicology] Scientists investigated the effects of miR-222-3p on the formation of medulloblastoma stem-like cells via the Notch2/c-myc pathway.

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