glioblastoma

[Nature Communications] Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.

[Radiotherapy and Oncology] Investigators suggested that combined treatment with the DRD2/3 antagonist ONC201 and radiation improves the efficacy of radiation against glioblastoma (GBM) in vitro and in vivo through suppression of glioma-initiating cells without increasing toxicity in mouse models of GBM.

[Cancer Cell] Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.

[Acta Neuropathologica Communications] Investigators interrogated gene expression in separate microenvironments of glioblastoma organoid models that mimicked the transition between nutrient-rich and nutrient-poor pseudopalisading/perinecrotic tumor zones using spatial-capture RNA-sequencing.

[Cancer Research] Scientists generated a herpes simplex 1-based oncolytic viruses expressing human IL-15/IL-15Rα sushi domain fusion protein, as well as off-the-shelf EGFR-CAR NK cells, and studied their monotherapy and combination efficacy in vitro and in multiple glioblastoma mouse models.

[PLOS ONE] Scientists proposed that IL-1β influences human umbilical cord Wharton's jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.