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Pulmonary Cell NewsResearchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
[Nature Communications]
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Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Ali Nabavizadeh, S., Bagley, S. J., Abdullah, K., Brem, S., Zhang, L., Xu, X., Byrne, K. T., Vonderheide, R. H., Gong, Y., & Fan, Y. (2021). Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications, 12(1), 3424. https://doi.org/10.1038/s41467-021-23832-3 Cite
