kidney disease

[Communications Biology] Co-cultured using a magnetic spheroid formation approach, conditionally immortalised human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.

[Cell Stem Cell] A functional dataset allowed improving mesoderm induction by ROCK inhibition, contained monogenetic and complex trait kidney disease genes, confirmed two additional congenital anomalies of the kidney and urinary tract genes, and provided a large candidate list of ciliopathy-related genes.

[Journal of Clinical Investigation] SIRT6-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease.

[JCI Insight] Scientists combined SARS-CoV-2 variants with genome edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics.

[American Journal of Nephrology] Investigators summarize the roles of the kynurenine pathway and its metabolites in acute kidney injury and chronic kidney disease based on current literature evidence.

[Nature Communications] Generation of kidney organoids from Tuberous Sclerosis Complex patient-derived-human iPSCs allowed researchers to recapitulate a rare kidney tumor called angiomyolipoma.