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lymphocytes

An Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Mycobacterium tuberculosis Exploiting Secreted Exosome Proteins

[Scientific Reports] An in-silico approach has been adopted to construct a multi-epitope vaccine from selected immunogenic extracellular vesicle proteins to elicit a cellular as well as a humoral immune response.

Immunological Mechanisms of Vaccine-Induced Protection against COVID-19 in Humans

[Nature Reviews Immunology] dentifying the mechanisms of protection as well as correlates of protection is crucially important to inform further vaccine development and guide the use of licensed COVID-19 vaccines worldwide.

Structure-Guided T Cell Vaccine Design for SARS-CoV-2 Variants and Sarbecoviruses

[Cell] Investigators applied structure-based network analysis and assessments of HLA class I-peptide stability to define mutationally constrained CD8+ T cell epitopes across the SARS-CoV-2 proteome.

Cord Blood and Amniotic Membrane Extract Eye Drop Preparations Display Immune-Suppressive and Regenerative Properties

[Scientific Reports] Both placental-derived allogeneic preparations, cord blood platelet lysate and amniotic membrane extract eye drops, display regenerative and immunomodulatory capabilities.

Dissecting Spatial Heterogeneity and the Immune-Evasion Mechanism of CTCs by Single-Cell RNA-Seq in Hepatocellular Carcinoma

[Nature Communications] Scientists revealed that the transcriptional dynamics of circulating tumor cells were associated with stress response, cell cycle and immune-evasion signaling during hematogeneous transportation.

COVID-19: Biologic and Immunosuppressive Therapy in Gastroenterology and Hepatology

[Nature Reviews Gastroenterology & Hepatology] Data on the use of immunosuppressive and biologic therapies for gastrointestinal diseases is discussed with a primary focus on inflammatory bowel disease, autoimmune hepatitis and liver transplantation.

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