Tag results:
lymphoid cells
Human Immunology News
Natural Killer Cell Immunosuppressive Function Requires CXCR3-Dependent Redistribution within Lymphoid Tissues
[Journal of Clinical Investigation] Scientists showed that natural killer (NK)-cell suppression of T cells is associated with transient accumulation of NK cells within T cell-rich sites of the spleen during lymphocytic choriomeningitis virus infection.
Umbilical & Placental Cell News
Episomal Vector Reprogramming of Human Umbilical Cord Blood Natural Killer Cells to an Induced Pluripotent Stem Cell Line MUSIi013-A
[Stem Cell Research] Natural killer cells were isolated from human umbilical cord blood from a healthy newborn and reprogrammed by episomal vectors carrying reprograming factors L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53 delivered using nucleofection.
Umbilical & Placental Cell News
Strongyloides stercoralis and HTLV-1 Coinfection in CD34+ Cord Blood Stem Cell Humanized Mice: Alteration of Cytokine Responses and Enhancement of Larval Growth
[PLOS Neglected Tropical Diseases] A model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established.
Immune Regulation News
Essential Role of a ThPOK Autoregulatory Loop in the Maintenance of Mature CD4+ T Cell Identity and Function
[Nature Immunology] The authors described a new autoregulatory loop whereby ThPOK bound to the SilThPOK to maintain its own long-term expression in CD4 T cells.
Immune Regulation News
LRRK2 Is Required for CD38-Mediated NAADP-Ca2+ Signaling and the Downstream Activation of TFEB (Transcription Factor EB) in Immune Cells
[Autophagy] Researchers mechanistically and functionally linked CD38 and LRRK2 as upstream activators of TFEB, a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.
Pulmonary Cell News
miR-526b-3p Inhibits Lung Cancer Cisplatin-Resistance and Metastasis by Inhibiting STAT3-Promoted PD-L1
[Cell Death & Disease] Researchers found that miR-526b-3p expression declined while programmed cell death protein ligand 1 (PD-L1) was elevated in cisplatin-resistant lung cancer compared to that in cisplatin-sensitive lung cancer by analyzing clinical samples.