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macrophages

Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair

[Advanced Healthcare Materials] A platelet lysate-rich plasma macroporous hydrogel scaffold with around 100 μm pore size and 1.25 MPa Young's modulus was developed to sustainedly recruit and polarize endogenous anti-inflammatory macrophages for improving cartilage defect repair.

M-CSFR/CSF1R Signaling Regulates Myeloid Fates in Zebrafish via Distinct Action of Its Receptors and Ligands

[Blood Advances] The authors investigated the roles of zebrafish colony-stimulating factor receptor (Csf1rs) and their ligands - Csf1a, Csf1b and Il34, in embryonic and adult myelopoiesis.

miR-125a-5p Attenuates Macrophage-Mediated Vascular Dysfunction by Targeting Ninjurin1

[Cell Death & Differentiation] Researchers investigated the role of Ninj1 in physiological and pathological conditions and developed a strategy to regulate Ninj1 using specific miRNAs under pathological conditions.

Enhanced Tendon Healing by a Tough Hydrogel with an Adhesive Side and High Drug-Loading Capacity

[Nature Biomedical Engineering] Investigators reported that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supported tendon gliding and strong adhesion to tendon on opposite surfaces of the hydrogel.

Systemic and Local Innate Immune Responses to Surgical Co-Transplantation of Mesenchymal Stromal Cells and Biphasic Calcium Phosphate for Bone Regeneration

[Acta Biomaterialia] Scientists assessed the local and systemic innate immune responses to implantation of biphasic calcium phosphate biomaterial alone, or with bone marrow derived MSC, in critical-sized calvarial bone defects of Lewis rats.

TMT-Based Quantitative Proteomic Profiling of Human Monocyte-Derived Macrophages and Foam Cells

[Proteome Science] Human peripheral blood mononuclear cells were stimulated with macrophage colony-stimulating factor, and obtained macrophages were transformed into foam cells by oxidized low-density lipoprotein.

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