mammary cells

[Scientific Reports] Breast cancer cells preferentially metastasize to bone. To study the bone-tumor paracrine influence, a tri-cellular 3-D vascularized breast cancer tissue model was engineered which comprised MDA-MB231, TNBCs, fibroblasts, and endothelial cells.

[Cell Death & Disease] To identify key immune players in the tumor microenvironment, investigators applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells.

[Cell Death & Disease] Investigators showed that the supernatant from ubiquitin-specific protease 12 (USP12)-overexpressing breast cancer cells could promote angiogenesis according to HUVEC migration and tube formation assays.

[Laboratory Investigation] Based on the immunohistochemical analysis of breast cancer tissues from 497 patients, the authors demonstrated that matrix metalloproteinase 11 (MMP11) expression in mononuclear inflammatory cells was an independent negative prognostic factor in breast cancer, whereas MMP11 expression in tumor cells and fibroblasts was not associated with patient survival.

[Scientific Reports] Researchers assessed the cellular sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for detection of MSCs and breast cancer cells.

[Journal of Controlled Release] Investigators engineered a photodynamic nanoplatform to manipulate breast cancer stem cells against tumor progression and metastasis by not only remolding the disequilibrium state but also blocking the epithelial-mesenchymal transition process.