monocytes

[Fulcrum Therapeutics, Inc.] Fulcrum Therapeutics, Inc. announced positive interim results from the ongoing single- and multiple-ascending dose Phase I trial with FTX-6058 in healthy adult volunteers.

[Science Translational Medicine] Investigators found that antiangiogenic treatment facilitated non–small cell lung cancer tumor infiltration by PD-1+ regulatory T cells, which were more efficiently targeted by the PD-1 antibody than CD8+ T cells.

[Scientific Reports] To evaluate the activation of Vγ9Vδ2 T cells by Lm-infected human monocyte-derived dendritic cells the authors engineered Lm strains that lacked components of the 2-C-methyl-D-erythritol 4- phosphate pathway.

[Nature Communications] Researchers showed a Pf ‘decision-sensing-system’ controlled by CXCL10 concentration. High CXCL10 expression prompted P. falciparum to initiate a survival strategy via growth acceleration.

[Scientific Reports] To investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.

[Diabetologia] The authors investigated whether fenofibrate increased circulating hematopoietic stem/progenitor cells (HSPCs). When compared with placebo, fenofibrate significantly increased levels of HSPCs expressing CD34 and/or CD133.