myeloid cells

[Cellular & Molecular Immunology] Scientists reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that TANK-binding kinase 1 (TBK1) served as a vital regulator of proinflammatory macrophage function and protected against tissue inflammation.

[Scientific Reports] The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.

[Nature Communications] The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.

[Scientific Reports] Investigators studied serum MMP3 and MMP9 as potential biomarkers of COVID-19 severity, in 108 hospitalized patients with different World Health Organization severity stage and in 48 controls.

[Molecular Therapy] Scientists showed that microRNA-26a inhibited pancreatic acinar cell store-operated Ca2+ entry channel expression, Ca2+ overload, and acute pancreatitis.