Tag results:
Natural Killer Cells
Muscle Cell News
Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Mouse Carotid Artery under Disturbed Flow
[Cell Death Discovery] Scientists investigated the heterogeneity of vascular cell populations under disturbed blood flow (d-flow). A d-flow-induced Spp1hi vascular smooth muscle cell subpopulation appeared to be endowed with osteoblast differentiation, suggesting a role in arterial stiffness.
Pulmonary Cell News
Downregulation of NKG2DLs by TGF-β in Human Lung Cancer Cells
[BMC Immunology] Scientists examined the expression of NKG2DLs, PD-L1 and PD-L2 in lung cancer cells after treatment of TGF-β and a TGF-β inhibitor, Galunisertib.
Cell Therapy News
INmune Bio, Inc. Announces First Patient Treated with NK Cell Priming “Pseudokine” INKmune in High-Risk Myelodysplastic Syndrome (MDS)
[INmune Bio, Inc.] INmune Bio, Inc. announced that the first patient has been treated in the company’s Phase I clinical trial of its Natural Killer cell priming platform, INKmune, as a potential treatment for high-risk myelodysplastic syndrome.
Human Immunology News
Genome-Scale Screens Identify Factors Regulating Tumor Cell Responses to Natural Killer Cells
[Nature Genetics] Researchers quantified the NK cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded’ solid tumor cell lines in multiplexed format and applied genome-scale CRISPR-based gene-editing screens in several solid tumor cell lines, to functionally interrogate which genes in tumor cells regulate the response to NK cells.
Extracellular Matrix News
Landscape of Innate Lymphoid Cells in Human Head and Neck Cancer Reveals Divergent NK Cell States in the Tumor Microenvironment
[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that peripheral circulating NK cells differentiated down two divergent pathways within the tumor microenvironment, resulting in different end states.
Immunology of Infectious Disease News
Bacterial Cytoplasmic Membranes Synergistically Enhance the Antitumor Activity of Autologous Cancer Vaccines
[Science Translational Medicine] To specifically trigger sufficient antitumor reactivity without notable adverse effects, scientists developed an antigen and adjuvant codelivery nanoparticle vaccine based on Escherichia coli cytoplasmic membranes (EMs) and tumor cell membranes (TMs) from resected autologous tumor tissue.