NF-κB

[Molecular Therapy] The authors reported that FOSL1, a component of activator protein 1 transcription factor complexes, was a key player in regulating proneural-to-mesenchymal transition.

[Stem Cell Reviews and Reports] Scientists found that pharmacological inhibition of NF-κB pathway in both control and CoCl2-treated mesenchymal stromal cells completely blocked their intercellular communication with the co-cultured HSCs and progenitor cells, resulting in an extremely poor output of hematopoietic cells.

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

[Nature Communications] By investigating the resistance mechanisms, scientists found that MCL1 and JUNB modulated the mitochondrial apoptosis pathway. JUNB encoded a transcription factor that downregulates FasL and TRAIL receptors, upregulated the MCL1 relative BCL2A1, and activated the NF-κB pathway.

[Science Advances] Using a reverse translational approach, investigators showed a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8–dependent mechanism.

[Experimental Dermatology] Researchers identified that circular RNA EIF5 (circEIF5) was highly expressed in psoriasis tissues compared to the normal skin.