obesity

[Human Cell] Researchers aimed to determine whether human umbilical cord-derived-MSCs-exosomes have a hepatoprotective effect on non-alcoholic fatty liver disease.

[Trends in Molecular Medicine] Scientists examine the evidence for altered mitochondrial dynamics as a mechanism in age and obesity-associated loss of skeletal muscle function, with a particular focus on the available human data.

[Scientific Reports] Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.

[Nature] Researchers showed that dietary fructose improved the survival of intestinal cells and increased intestinal villus length in several mouse models. In hypoxic intestinal cells, fructose 1-phosphate inhibited the M2 isoform of pyruvate kinase to promote cell survival.

[Nature Communications] Visceral adipose-derived factors promoted vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibited miR-200a and enhanced ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.

[Scientific Reports] Scientists tested whether selective hematopoietic upstream stimulatory factor 1 (USF1) deficiency could also beneficially impact the development of atherosclerosis. Absence of USF1 function in bone marrow-derived cells was associated with exacerbated blood leukocyte and peritoneal leukocyte lipid loading and an increased atherosclerosis susceptibility.