SARS-CoV-2

[Trends in Molecular Medicine] Scientists summarize what is known about the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and of acute COVID-19, and speculate that the pathogenesis of post-COVID-19 syndrome in some people may be similar to that of ME/CFS.

[Science Translational Medicine] Researchers reported evidence that the olfactory neuroepithelium was a major site of SARS-CoV2 infection with multiple cell types, including olfactory sensory neurons, support cells, and immune cells, becoming infected.

[Science Translational Medicine] Investigators showed that early-phase SARS-CoV-2 spike protein–specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages.

[Science Advances] The authors report ed cryo-EM structures of both trimeric spike ectodomains in complex with the 47D11 Fab. 47D11 bound to the closed receptor-binding domain, distal to the ACE2 binding site.

[Journal of Clinical Investigation] Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells develop excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.

[Heliyon] Researchers ivestigated the immune response in acute or convalescent COVID19 patients. They characterized the peripheral blood mononuclear cells using flow cytometry and found that CD8+ T cells were significantly subsided in moderate COVID-19 and convalescent patients.